Track: Life Sciences
Role of Network Analysis and Monte-Carlo Simulation in Target Profile Research in Pharmaceuticals
Wednesday, April 14, 11-11:40am EDT
The Target Product Profile (TPP) is a concise communication tool designed to demonstrate what is required for success in a future marketplace. It is a simple document that embeds future market needs that consider critical external stakeholders and ensures that we develop medicines with a specific advantage. Teams invest significant time and resources in collecting external stakeholders’ perspectives through primary research, typically in in-depth interviews with clinicians. These interviews help define minimal thresholds of success and establish desired endpoints for differentiation in a clinical development program. The parameters of success established early in a clinical program tend to evolve, requiring teams to revalidate assumptions about the future marketplace needs. Network analysis that assimilates publicly available external aggregate clinical trial results combined with Monte-Carlo simulation into a predictive model allows for analysis of compounds in a future marketplace. Network analysis of aggregated clinical trial results can offer additional guidance to teams before these teams invest in collecting external stakeholders’ perspectives through primary research.